The GcMAF Book

References

Nobuto Yamamoto References

Nobuto Yamamoto, Naofumi, Ushijima, and Yoshihiko Koga. Immunotherapy of HIV-infected patients with Gc protein-derived macrophage activating factor (GcMAF). Serum Gc protein (known as vitamin D3-binding protein) is the precursor. J Med Virol. Jan; 81(1):16-26. 2009.

Yamamoto N, Suyama H, Nakazato H, Yamamoto N-Y, Koga Y. 2008c. Immunotherapy of metastatic colorectal cancer with vitamin Dbinding protein-derived macrophage-activating factor, GcMAF. Cancer Immunol Immunother 57:1007–1016.

Yamamoto N, Suyama H, Yamamoto N-Y. 2008b. Immunotherapy of prostate cancer with Gc protein-derived macrophage-activating factor, GcMAF. Translational Oncol 1:65–72.

Yamamoto N, Suyama H, Yamamoto N-Y, Ushijima N. Immunotherapy of metastatic breast cancer patients with vitamin D-binding protein-derived macrophage-activating factor, (GcMAF). Int J Cancer 2008 Jan 15;122(2):461-7.

Yamamoto N, Ueda M, Benson CE. 2007. Treatment of HIV-infected patients with Gc protein-derived macrophage activating factor (GcMAF) eradicates HIV-infection. Proc 13th Int Cong Immunol. Italy: Medimond, Bologna. pp. 35–38.

Nobuto Yamamoto, Masahiro Urade, Yoshihiko Koga, Nobuyuki Yamamoto, Theodor Sery and Masumi Ueda. Macrophages Activated By GCMAF Develop Enormous Variation of Receptors That Recognize and Eradicate Adenocarcinomas. Clinical Immunology, Volume 119, Supplement 1, 2006, Page S96. FOCIS 2006 Abstract Supplement - 6th Annual Meeting.

Yamamoto, Masahiro Urade, Yoshihiko Koga, Nobuyuki Yamamoto, Theodor Sery and Masumi Ueda. Macrophages Activated By GCMAF Develop Enormous Variation of Receptors That Recognize and Eradicate Adenocarcinomas. Nobuto 2006.

Yamamoto N.. Pathogenic significance of a-N-acetylgalactosaminidase found in the envelope glycoprotein gp160 of human immunodeficiency virus type 1. AIDS Res Human Retroviruses 22:262–271, 2006.

Yamamoto N, Urade M. 2005. Pathogenic significance of a-Nacetylgalactosaminidase found in the hemagglutinin of influenza virus. Microbes Infect 7:674–681.

Yamamoto N, Urade M, Ueda M. 2005. Potent tumoricidal capacity of macrophages activated by Gc protein-derived macrophage activating factor (GcMAF) and its therapeutic efficacy for prostate, breast, and colorectal cancers. J Immunother 28:642.

Nobuto Yamamoto, Masahiro Urade. Microbes and infection. Institut Pasteur 7 , 4: 674-81, Apr 2005

Yamamoto N, Ueda M. 2004b. Eradication of HIV by treatment ofHIVinfected/AIDS patients with vitamin D-binding protein (Gc protein)-derived macrophage activating factor (GcMAF). Immunology. Italy: Medmond, Bologna. pp. 197–200.

Yamamoto N, Ueda M. 2004a. Therapeutic efficacy of vitamin Dbinding protein (Gc protein)-derived macrophage activating factor (GcMAF) for prostate and breast cancers. Immunology. Italy: Medmond, Bologna. pp. 201–204.

Nobuto Yamamoto and Masumi Ueda. Cancer cell-killing by macrophages treated with Gc protein-derived macrophage activating factor (GcMAF) Proc Amer Assoc Cancer Res, Volume 45, 2004. Experimental and Molecular Therapeutics 11: Specific Immune Mechanisms and Cancer Vaccines: Clinical Studies Abstract #1255

Yamamoto N. 2002. Preparation of potent macrophage activating factor derived from cloned vitamin D binding protein and its domain and their therapeutic usage for cancer, HIV-infection and osteopetrosis. U.S. Patent Number: 6,410,269.

Shigeru Kanda, Yasushi Mochizuki, Yasuyoshi Miyata, Hiroshi Kanetake, Nobuto Yamamoto. Effects of Vitamin D3-Binding Protein-Derived Macrophage Activating Factor (GcMAF) on Angiogenesis. Journal of the National Cancer Institute, Vol. 94, No. 17, 1311-1319, September 4, 2002.

Koga Y, Naraparaju VR, Yamamoto N. 1999. Antitumor effects of vitamin D3-binding protein-derived macrophage activating factor on Ehrlich tumor bearing mice. Proc Soc Exp Biol Med 220:20–26.

Yamamoto N. 1999. Diagnostic and prognostic ELISA assays of serum a-N-acetylgalactosaminidase for AIDS. U.S. Patent Number: 5,985,545.

Yamamoto N. 1998b. Diagnostic and prognostic ELISA assays of serum or plasma a-N-acetylgalactosaminidase for cancer. U.S. Patent Number: 5,712,104.

Yamamoto N, Naraparaju VR. 1998. Structurally well-defined macrophage activating factor derived from vitamin D3-binding protein has a potent adjuvant activity for immunization. Immunol Cell Biol 76:237–244.

Yamamoto, Nabuto; Naraparaju, Venka Tenkateswara, R. Structurally well-defined macrophage activating factor derived from vitamin D3-binding protein has a potent adjuvant activity for immunization. Special Feature. Immunology & Cell Biology. 76(3):237-244, June 1998.

Nobuto Yamamoto, Venkateswara R. Naraparaju and Masahiro Urade. Prognostic Utility of Serum a-N-Acetylgalactosaminidase and Immunosuppression Resulted from Deglycosylation of Serum Gc Protein in Oral Cancer Patients. Cancer Research 57, 295-299, January 15, 1997.

Yamamoto N. 1997. Diagnostic and prognostic indices for cancer and AIDS. U.S. Patent Number: 5,620,846. Yamamoto N. 1998a. Vitamin D and the immune system. In: Encyclopedia of Immunology. 2nd edition. Delves PJ, Roitt I, editors. Academic Press Ltd. London: pp. 2494–2499.

Yamamoto N, Naraparaju VR, Urade M. 1997. Prognostic utility of serum a-N-acetylgalactosaminidase and immunosuppression resulted from deglycosylation of serum Gc protein in oral cancer patients. Cancer Res 57:295–299.

Yamamoto N, Naraparaju VR. 1997. Immunotherapy of BALB/c mice bearing Ehrlich ascites tumor with vitamin D3-binding proteinderived macrophage activating factor. Cancer Res 57:2187–2192.

Nobuto Yamamoto, Venkateswara R. Naraparaju, Mary Moore and Lawrence H. Brent. Deglycosylation of Serum Vitamin D3-Binding Protein by alpha-N Acetylgalactosaminidase Detected in the Plasma of Patients with Systemic Lupus Erythematosus. Clinical Immunology and Immunopathology Volume 82, Issue 3, March 1997, Pages 290-298.

Korbelik M, Naraparaju VR, and Yamamoto N (1997). Macrophage-directed immunotherapy as adjuvant to photodynamic therapy of cancer. Br J Cancer 75, 202 – 207.

Yamamoto, N., Naraparaju, V. R., and Asbell, S. 0. Deglycosylation of serum vitamin D3-binding protein leads to immunosuppression in cancer patients. Cancer Res.,56:2827-2831,1996.

Yamamoto, N., and Naraparaju, V. R. Role of mouse vitamin D3-binding protein in activationof macrophages. J. Immunol.,157: 1744-1751,1996.

Yamamoto N. 1996. Structural definition of a potent macrophage activating factor derived from vitamin D3 binding protein with adjuvant activity for antibody production. Mol Immunol 33:1157–1164.

Koga, Y., Naraparaju, V. R., and Yamamoto, N. Antitumor effects of vitamin D3-binding protein-derived macrophage activating factor on Ehrlich tumor bearing mice. Cancer Research Proc., 37: 481, 1996.

Yamamoto, N., Naraparaju, V. R., and Srinivasula, S. M. Structural modification of serum vitamin D1-binding protein and immunosuppression in AIDS patients. AIDS Ret. Hum. Retroviruses, 11: 1373-1378,1995.

Yamamoto. N., Willen, N. P., and Lindsay, D. D. Participation of serum proteins in the inflammation-primed activation of macrophages.Inflammation, 8: 311-322, 1994.

Naraparaju VR, Yamamoto N. 1994. Roles of b-galactosidase of B lymphocytes and sialidase of T lymphocytes in inflammation primed activation of macrophages. Immunol Lett 43:143–148.

Yamamoto N, Kumashiro R.. Conversion of vitamin D3 binding protein (Group! specific component) to a macrophage activating factor by the stepwise action of b-galactosidase of B cells and sialidase of T cells. J Immunol 151:2794–2802, 1993.

Yamamoto N. 1993. In vitro enzymatic conversion of glycosylated human vitamin D binding protein to a potent macrophage activating factor. U.S. Patent Number: 5,177,002.

Homma, S., Yamamoto, M., and Yamamoto, N. Vitamin D binding protein (group specific componen is the sole serum protein required for macrophage activation after treatment of peritoneal cells with lysophosphatidylcholine. Immunol. Cell Biol.,71: 249-257, 1993.

Yamamoto, N., Kumashiro, R., Yamamoto, M., Willett, N. P., and Lindsay, D. D. Regulation of inflammation-primed activation of macrophages by two serum factors, vitamin D3-binding protein and albumin. Inf. Imm., 61: 5388-5391, 1993.

Yamamoto, N., and Homma, S. Vitamin D3 binding protein (group-specific component, Gc) is a precursor for the macrophage activating signal factor from lysophosphatidylcholine-treated lymphocytes.Proc. NatI. Acad. Sci. USA, 88: 8539-8543, 1991.

Yamamoto N, Homma S, Millman I. 1991. Identification of the serum factor required for in vitro activation of macrophages: Role of vitamin D3 binding protein (Group specific component, Gc) in lysophospholipid activation of mouse peritoneal macrophages. J Immunol 147:273–280.

Yamamoto N, Homma S. 1991. Vitamin D3 binding protein (groupspecific component,Gc) is a precursor for the macrophage activating signal factor from lysophosphatidylcholine-treated lymphocytes. Proc Natl Acad Sci USA 88:539–543.

Homma S, Yamamoto N. 1990. Activation process of macrophages after in vitro treatment of mouse lymphocytes with dodecylglycerol. Clin Exp Immunol 79:307–313.

Ngwenya, B. Z., and Yamamoto, N. Contribution of lysophosphatidylcholine-treated nonadherent cells to mechanism of macrophage activation. Proc. Soc. Exp. Biol. Med.,193:118-124, 1990.

Yamamoto N, St., Claire DA, Homma S, Ngwenya BZ. 1988. Activation of mouse macrophages by alkylglycerols, inflammation products of cancerous tissues. Cancer Res 48:6044–6049.

Matsui T, Nakashima H, Yoshiyama H, Kobayashi N, Yamamoto N. 1987. Plaque staining assay for non- or weakly cytotoxic human immunodeficiency virus. J Clin Microbiol 25:1305–1307.

Yamamoto, N., Ngwenya, B. Z., Sery, 1. W., and Pieringer R. A. Activation of macrophages by ether analogues of lysophospholipids. Cancer Immunol. Immunother. 2,5: 185-192, 1987.

Yamamoto, N., and Ngwenya, B. Z. Activation of macrophages by lysophospholipids and ether derivatives of neutral lipids and phospholipids. Cancer Res., 47: 2008-2013,1987.

Ngwenya, B. Z., and Yamamoto N. Effects of inflammation products on immune systems: lysophosphatidylcholine stimulates macrophages. Cancer Immunol. Immunother., 21: 1074-1082, 1986.

Harada S, Purtilo D, Koyanagi Y, Sonnabend J, Yamamoto N. 1986. Sensitive assay for neutralizing antibodies against AIDS-related viruses (HTLV-III/LAV). J Immnol Methods 92:177–181.

Ngwenya, B. Z., and Yamamoto, N. Activation of peritoneal macrophages by lysophosphatidylcholine. Biochim. Biophys. Acts 839: 9-15,1985.

Sato M, Tanaka H, Yamada T, Yamamoto N. 1977. Persistent infection of BHK/WI-2 cells with rubella virus and characterization rubella variants. Arch Virol 54:333–343.

Korbelik M, Naraparaju VR, and Yamamoto N (1997). Macrophage-directed immunotherapy as adjuvant to photodynamic therapy of cancer. Br J Cancer 75, 202 – 207.

Yamamoto N, and Homma S (1991). Vitamin D3 binding protein (group-specific component) is a precursor for the macrophage-activating signal factor from lysophosphatidylcholine-treated lymphocytes. Proc Natl Acad Sci USA 88, 8539 – 43.

Yamamoto N, Hoober JK, Yamamoto N, and Yamamoto S (1992). Tumoricidal capacities of macrophages photodynamically activated with hematoporphoryin derivative. Photochem Photobiol 56, 245 – 50.

Yamamoto N, and Naraparaju VR. Immunotherapy of BALB/c mice bearing Ehrlich ascites tumor with vitamin D- binding protein -derived macrophage activating factor. Cancer Res 57, 2187–92, 1997.

Koga Y, Naraparaju VR, and Yamamoto N (1999). Antitumor effect of vitamin D- binding protein - derived macrophage activating factor on Ehrlich ascites tumor - bearing mice. Proc Soc Exp Biol Med 220, 20–26.


Other references

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AMAS articles—most authored by Samuel Bogoch, M.D. PhD.

Astrocytin and malignin: Two Polypeptide Fragments (Recognins) Related to Brain Tumor. National Cancer Institute Mon. 46:133-137, 1977.

Disarmed anti-malignin antibody in human cancer. Lancet. 1979 May 5;1(8123):987.

Monoclonal Anti-Malignin Antibodies. The Lancet 2:141-142, 1981.

Determination of Anti-Malignin Antibody and Malignin in 1,026 Cancer Patients and Controls: Relation of Antibody to Survival. J. Medicine 13:49-69, 1982.

Anti-Malignin Antibody and Scantag. Protides Biol. Fluids 30:337-352, 1983.

Elevated Levels of Anti-Malignin Antibody are Quantitatively Related to Longer Survival in Cancer Patients. Protides Biol. Fluids 31:739-747, 1984.

In Vitro Production of the General Transformation Antibody Related to Survival in Human Cancer Patients: Anti-Malignin Antibody (AMA). Cancer Detection and Prevention 18:Number 5/6, 551, 1985.

Increased Accuracy of Anti-Malignin Antibody Determination in Unstored Sera Permits Screening” Cancer Detection and Prevention. 11:Number 1/2, 85, 1987.

In Vitro Production of the General Transformation Antibody Related to Survival in Human Cancer Patients: Antimalignin Antibody Cancer Detection and Prevention 12:313-320,1988.

Malignin antibody and early malignancy. The Lancet 337:977,1991.

Malignin Antibody Returns to Normal After Successful Treatment of Breast Cancer. Cancer Detection and Prevention 17(l):180,1993.

Malignin Antibody As Early Warning. Cancer Detection and Prevention 17(l): 229,1993.

Comparison of Antimalignin With Other Markers for Early Detection and Surrogate Endpoint Use in Chemoprevention Trials for Breast, Colon, and Prostate Cancer. J. Cell Biochem. 19:61,1994 (National Cancer Institute Symposium)

Early Detection and Monitoring of Cancer with the Anti-Malignin Antibody Test. Detection and Prevention: 18(l):65-78,1994.

A Checklist for Suitability of Biomarkers as Surrogate Endpoints in Chemoprevention of Breast Cancer. J. Cell. Biochem 19:172-185,1994. (National Cancer Institute Symposium)

Aglyco Pathology of Viral Receptors in Dementias. In Functional Diversity of Interacting Receptors. New York Academy of Sciences 757:413-417,1995.

Return of Elevated Antimalignin Antibody to Normal Indicates Remission of Breast Cancer. American Association for Cancer Research 37:486,1996.

Antimalignin Antibody (AMAS®) Elevation Detects Persistent or Recurrent Breast Cancer. Cancer Detection and Prevention 20(5):508-509,1996.

A New Era for Cancer Diagnosis and Treatment Based Upon Earlier, Asymptomatic, Detection. J. Adv. Med. 10:149-150,1997.

Production of a Synthetic General Cancer Vaccine Which Augments the Concentration of Antimalignin Antibody In Vivo. Cancer Detection and Prevention 22(l):S-227,1998.

A Quantitative Immune Response in Human Cancer. Cancer Detection and Prevention 22(l):S-159,1998.

Copyright © 2010 Timothy J. Smith, M.D.