The GcMAF Book


Routine Nagalase testing finds cancer early and GcMAF cures it

If we can accelerate research on Nagalase testing and GcMAF treatment, the following conversations might happen five years from now:

Joe has an appointment with Dr. Jones, his family doctor for the past two decades, to discuss Joe’s annual lab test results.

“Hi Joe. Good to see you!” says Dr. Jones. “We ran some screening tests on your blood and I’ve got some good news and some bad news.”

“It’s been a long day, doc. How about the good news first, if you don’t mind,” says Joe.

“Sure. Your blood tests tell me you are a picture of health. Your cholesterol and other heart markers are all normal. Your vitamin D level is excellent at 70. Your PSA is low. Your thyroid is in balance. Your complete blood count and other metabolic parameters are perfect.”

“Sounds good, doc, and that all fits perfectly with the fact that I feel great! …so what’s the bad news?”“

“Well, Joe, your Nagalase level is elevated. and that’s got me a little concerned.”

“My Nagalase is elevated? What is that and what does that mean?” says Joe cautiously.

“Nagalase—short for alpha-N-acetylgalactosaminidase—is an enzyme made by viruses and cancer cells. We can test for it. An elevated level tells me you have the very earliest beginnings of either a cancer or a virus.

Nagalase testing is a lot like cholesterol testing. Elevated cholesterol is associated with increased risk of arterial plaque and heart attack. An elevated Nagalase tells us you are at increased risk of cancer.

“Cancer or virus? I don’t understand. What does that mean, doc?”

“Both cancers and viruses make Nagalase, and at this point I can’t tell you which it is. But there’s nothing to worry about here, Joe. You don’t have any symptoms, so it probably isn’t a virus. We’ll get some antibody tests to rule out that possibility, and we’ll repeat your Nagalase level to see whether it is going up or not. For now, all we need to do is keep an eye on everything. If the elevation is caused by a virus, the level will go back down. If the elevated Nagalase is caused by an early cancer, the Nagalase will keep going up, and we’ll treat it and make it go away. Here’s your lab order. See you in a month, okay?”

“Should I be worried, doc?”


“I might have cancer, but not to worry? How does that work?”

“Five years ago, Joe, I’d be very concerned. But back then we didn’t have Nagalase testing for detecting early cancers, so I wouldn’t have even known that a cancer was getting started in you. At least not until it got a lot bigger. And five years ago, if I did have some way to know you had early cancer, I wouldn’t have had a way to reverse it. Now, I have both. And I must tell you, as a doctor who has seen a lot of people suffer and die from cancer, we are extremely fortunate that these tools are now available. Millions of olives have already been saved by catching cancers early and reversing them before they got out of control. So, not to worry, Joe. If it’s cancer, we have the tools to get rid of it. See you in a month.”


One month later

“Joe, your viral antibody tests all came back normal, so now we know you don’t have a viral infection. Your Nagalase, however, continues to climb higher. That tells me you have a very small early stage cancer growing in you somewhere.”

“I’ve got cancer? Yikes! You did tell me this was a possibility. Now should I be worried?”

“No, Joe, you really have nothing to worry about. We have a treatment that will make this cancer go away. And we can accomplish that long before it gets big enough to show up on a CAT scan.”

“Does it matter what kind of cancer it is?”


“Does it matter where it is located?”


“Shouldn’t I get a CAT scan so we can find it?”

“Since your Nagalase is only slightly elevated, I know that your cancer’s still way too small to see on imaging. But the cancer cells are definitely in there, making the Nagalase that we see on your blood test.”

Couldn’t there be something else that’s making the Nagalase?” says Joe.

“No, Nagalase is only made by cancers and viruses, and we’ve eliminated the possibility of a virus, so it has to be cancer.”

“How soon can we start treating it?”

“In one month. I want to get a third Nagalase level, just to make sure—and if it is still going up, then we can be certain it is cancer, and we’ll start the treatment.”

Another month goes by…

“Well, Joe, your Nagalase is still climbing, so we can start treatment today.”

“Okay. What do we do? What is the treatment?”

“Weekly injections of GcMAF. We’ll keep on measuring your Nagalase once a month, and when it gets back down to normal, we’ll know the cancer has been cured, so that’s when we’ll stop giving you the shots.”

“How long does that take?”

“Usually three to six months.”

“What is GcMAF, anyway?”

“GcMAF—group specific component macrophage activating factor—is the protein your body makes to activate your anti-cancer immune activity…

“Anti-cancer immune activity. What’s that, Dr. Jones?”

“Joe, your immune system contains some very large cells called macrophages that, when activated, will track down, attack, devour, and kill viruses and cancer cells. GcMAF—an immune protein made by your lymphocytes—is what literally turns them on. Without GcMAF, your macrophages remain in a state of suspended animation—sort of like zombies.”

“You mean if I don’t have enough GcMAF they stop killing off the invaders? That can’t be good.”

“No, it isn’t, Joe. This is not a subtle slowdown, either. In terms of killing power, an activated macrophage is about 40 times more aggressive than a de-activated macrophage. Without GcMAF, they just go to sleep.”


“Your cancer cells have figured out that if they block the production of GcMAF, they can disable their archenemies, the macrophages, and get the upper hand. Without GcMAF to activate them, the macrophages don’t have a chance.”

“So, doc, how did they do it? How did my cancer cells disable my macrophages.”

“By making Nagalase.”

“The same stuff you’ve been testing?”

“Yup. Nagalase blocks GcMAF production, so when we see a rising Nagalase, we pay very close attention. It is an incredibly sensitive test, and it tells us cancer is on the move. As cancers grow, they generate more and more Nagalase.”

“So the rising Nagalase numbers told you my cancer cells were winning the war.”

“Yes.” replies Dr. Jones.

“And that the Nagalase had put my macrophages to sleep by blocking my body’s GcMAF production.”

“Right. There may be a future for you in molecular biology, Joe.”

“So how do we re-/activate my macrophages so they get back to work destroying my cancer cells?”

“By giving you weekly injections of GcMAF, to bypass the production blockage caused by the Nagalase.”

“Makes sense to me. How big are these shots, doc?”

“They’re incredibly small. Just 100 nanograms—that’s 100 billionths of a gram, dissolved in a few drops of water. In fact, if you removed the water, the GcMAF alone would be too small to see.”


“And this stuff really works?”

“In early cases like yours, Joe, it works every time. That’s why we like to catch it while it’s still small using Nagalase screening.”

“So you are going to give me some GcMAF shots that’ll perk up my macrophages so they can get back to work finding and gobbling up these cancer cells, right?”

“Right. Now, please roll up your sleeve.”

How GcMAF works: GcMAF is the protein that activates macrophages and jump-starts the entire immune response. To sabotage the immune system and put the macrophages to sleep, all cancers and viruses make Nagalese, the enzyme that blocks production of GcMAF. In the absence of GcMAF, cancers, HIV, and other viruses can grow unimpeded. Dr. Nobuto Yamamoto demonstrated that GcMAF administration bypasses the Nagalese blockage and re-activates the macrophages, which then proceed to kill the cancer cells and HIV viruses:


GcMAF cures Mary’s metastatic breast cancer

“Hi Mary.”

“Hi Doc.”

“Good to see you. As you already know, we had found that small breast cancer on your mammogram, and Dr. Humphrey has already taken it out.”


“As you also know, I got a Nagalase level before the lumpectomy, and then again after surgery, and then monthly levels since. Because the Nagalase level is always directly proportional to the amount of cancer in your body, it really helps me to track your cancer and make sure it doesn’t get out of control.”

“Yes, and remember how high it was right before my surgery? Then, right after the surgery, it dropped a lot, because there was less cancer to make the Nagalase. But it was still elevated after the lump was taken out, so we knew there still had to be some cancer left behind after the surgery, darn it. And then my Nagalase started climbing again, so we knew the cancer, wherever it was—was growing. That part was pretty depressing, doc! That’s why you started me on the GcMAF, right?

“Yes. And as you know, Mary, we’ve been testing your Nagalase levels monthly since we started the GcMAF shots, and it has been gradually coming back down. This told me that the GcMAF was activating your immune system and that your macrophages—if you’ll excuse the expression—were in there kicking butt on your cancer cells.”

“No problem, doc, it is pretty exciting.

“I’ve got some really good news for you today, Mary. Your Nagalase level has finally, after 20 weeks of injections, reached zero. You are now officially cancer-free, so we can stop the injections. And we can celebrate! If you don’t mind my saying so, YIPPEE!!!

“Wow! That’s incredible. You know, Doc, I might have been dead right now if it weren’t for you …and the GcMAF. Thank you so much!

“Mary, it is sincerely my pleasure.”

Copyright © 2010 Timothy J. Smith, M.D.
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