The GcMAF Book (2.0)

Chapter 10

How Nagalase Blocks GcMAF Production

Cancer cells and all viruses manufacture and release Nagalase, the enzyme that sabotages GcMAF. Without GcMAF, macrophages remain in a deep slumber. This chapter answers the question: “How does Nagalase do it?”

Nagalase sabotage

As you know by now (because I have reiterated it ad nauseum), the Nagalase spewed out by cancer cells and virus particles neutralizes the immune-activating effects of GcMAF. For millions of years GcMAF (and our immune systems) have had no defense against Nagalase. Then Professor Nobuto Yamamoto came along and figured out how Nagalase paralyzes immune functioning. He then went on to demonstrate that replacing the GcMAF deficiency dramatically restores immune function, effectively circumventing the roadblock set up by Nagalase.

The ultra-miniature Nagalase power play that I’m about to describe has leverage far beyond its trifling size. This relatively simple molecular biological enzymatic reaction has cost billions of humans their lives. Who would’ve thought that chipping a few sugars off of a glycoprotein molecule could have wreaked such carnage?

A saboteur is one who intentionally causes the destruction of property in order to hinder the efforts of his/her enemy. The word derives from 15th century Netherlands, where, fearing that automated machines would render their occupations obsolete, Dutch workers threw their sabots (wooden shoes) into the gears of the textile looms in an attempt to break the cogs. Likewise, Nagalase, the saboteur, “throws a boot” into the biochemical machinery that produces GcMAF.

Like taking candy from a baby

Now I will describe—on a molecular “blow by blow” basis—how Nagalase blocks GcMAF production. Recall from Chapter 8: How Your Body Makes GcMAF that our lymphocytes make GcMAF by enzymatically removing two of three sugars from a Vitamin D Binding Protein (DBP) molecule:


Vitamin D Binding Protein is converted to GcMAF.

To appreciate how Nagalase interferes with GcMAF production, imagine that DBP is the baby that is about to be blocked from becoming GcMAF. Baby GcMAF (AKA DBP) is trying to hold onto its Hershey’s bar (AKA N-acetylgalactosamine). Nagalase comes along and snatches all three sugars away from the “baby.” (See illustration below.) The sugars float away, off into the cellular soup, never to be heard from again. (Oh, I imagine sooner or later—as with other sugars—they’ll be burned up in a mitochondrial factory to generate a little cellular energy—but as far as DBP is concerned, they’re Gone.)


Nagalase blocks GcMAF production by deglycosylating Vitamin D-Binding Protein.

When the dust settles, we are also left with a worthless “deglycosylated” DBP molecule. With all of its sugars removed by the Nagalase, there’s no way DBP can become GcMAF. Thanks to the saboteur Nagalase, all that remains is a useless, sugar-free protein that can’t be converted into anything of value. It too drifts off into cellular obscurity and eventually gets recycled.

In its underhanded effort to subvert the immune army, Nagalase has literally stooped to snatching candy from a baby. The fetus (DBP) that would have become GcMAF has died in utero. And, Voila! The pathogen has neutralized it’s enemy’s immune system. The cancer cell or virus that made the Nagalase has succeeded in neutralizing its archenemy, the macrophage. And (as pointed out earlier, but bears repeating), when macrophages are de-activated, cell signaling is simultaneously deactivated, so other immune cells (primarily B- and T- lymphocytes) stop functioning too. Anti-cancer and antimicrobial immune activity have been effectively disabled.

Nagalase is remarkably efficient

Because it is an enzyme—a catalyst—Nagalase performs this malicious ritual over and over and over again, and each time it comes away unscathed and unchanged. One Nagalase molecule can thus destroy a huge quantity of GcMAF precursor molecules.

To appreciate how precisely Nagalase (Alpha-N-acetylglucosaminidase) targets GcMAF production, imagine a Stinger heat-seeking ground-to-air missile tracking a fighter jet. Evasive maneuvers—even by the best pilots—won’t outsmart the Stinger, which rapidly adjusts its course to track the plane down and blow it up. Nagalase works the same way: it tracks down and then pulverizes the (DBP) precursors of GcMAF molecules.

Nagalase has no natural enemies. No bodily process, no drug, no treatment could outsmart this diabolical killer. Sure, high-powered drugs and radiation will take out many of the cancer cells and in some cases produce a cure, but until Dr. Nobuto Yamamoto came along and outed Nagalase, we had no idea as to the actual cause of the immune shutdown that let cancers and viruses go wild.


Dr. Yamamoto’s schematic diagrams for the production of GcMAF. FIG. 1A: The formation of GcMAF from Gc protein (vitamin D binding protein. FIG. 1B: The deglycosylation of Gc protein by Nagalase (alpha-N-acetylgalactosaminidase).

Copyright © 2010 Timothy J. Smith, M.D.
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